vav-2 proto-oncogene protein (VAV2)

Function

• guanine nucleotide exchange factor for the Rho family of Ras-related GTPases

Structure

• contains 1 CH (calponin-homology) domain
• contains 1 DH (DBL-homology) domain
• contains 1 PH domain
• contains 1 phorbol-ester/DAG-type Zn+2 finger
• contains 1 SH2 domain
• contains 2 SH3 domains

Expression

widely expressed

More general terms

• DNA-binding protein
• transcription factor (TF)
• proto oncogene protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7410
• OMIM: https://mirror.omim.org/entry/600428
• UniProt: http://www.uniprot.org/uniprot/P52735.html