phosphoinositide 3-kinase regulatory subunit 6 (phosphoinositide 3- kinase gamma adapter protein of 87 kD, p87 PI3K adapter protein, p87PIKAP, PIK3R6, C17orf38)

Function

• regulatory subunit of the PI3K gamma complex
• heterodimer with PIK3CG (catalytic subunit)
• adapter for activation of PIK3CG by G beta gamma proteins
• interacts with PDE3B & G beta gamma proteins
• binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG

Compartment

cytoplasm (putative)

More general terms

• enzyme regulatory subunit

Component of

• phosphoinositide-3-kinase (phosphatidylinositol-3-kinase, PI3K)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1468
• UniProt: http://www.uniprot.org/uniprot/Q5UE93.html