cGMP-inhibited 3',5'-cyclic phosphodiesterase B; CGIPDE1; CGIP1; cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B (PDE3B)

Function

• cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP & cGMP
• may play a role in fat metabolism

nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2

Inhibition:

• inhibited by cGMP

Structure

• belongs to the cyclic nucleotide phosphodiesterase family, PDE3 subfamily

Compartment

membrane

Expression

• abundant in adipose tissues

More general terms

• phosphodiesterase 3; cGMP inhibited phosphodiesterase (PDE3)
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5140
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5140
• OMIM: https://mirror.omim.org/entry/602047
• UniProt: http://www.uniprot.org/uniprot/Q13370.html