phospholemman; FXYD domain-containing ion transport regulator 1 (FXYD1 PLM)

Function

• induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes
• may have a functional role in muscle contraction
• major plasma membrane substrate for protein kinases in several different tissues
  • cAMP-dependent protein kinase
  • protein kinase C
• phosphorylated in response to insulin & adrenergic stimulation

Structure

belongs to the FXYD family

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• highest expression in skeletal muscle & heart
• moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine & colon with mucosal lining. very low levels in kidney, colon & small intestine without mucosa, prostate without endothelial lining, spleen, & testis

More general terms

• carrier protein (transporter)
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5348
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5348
• OMIM: https://mirror.omim.org/entry/602359
• UniProt: http://www.uniprot.org/uniprot/O00168.html