tricarboxylate transport protein, mitochondrial; citrate transport protein; CTP; tricarboxylate carrier protein; solute carrier family 25 member 1 (SLC25A1, SLC20A3)
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Function
- role in citrate-H+/malate exchange
- role in bioenergetics of hepatic cells as it provides a carbon source for fatty acid & sterol biosyntheses, & NAD+ for the glycolytic pathway
Structure
- belongs to the mitochondrial carrier family
- contains 3 solcar repeats
Compartment
mitochondrial inner membrane
Pathology
- reduced histone acetylation due to impaired export of mitochondrial acetyl-CoA with age in mesenchymal stem cells due to lower levels of citrate carrier[3]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P53007.html
- ↑ Principles of Biochemistry 6th ed., White, Handler, Smith, Hill, & Lehman (eds.) McGraw-Hill, NY 1978, pg 345
- ↑ 3.0 3.1 Pouikli A, Parekh S, Maleszewska M et al Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nat Aging. 2021 Sep;1(9):810-825 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37117628 PMCID: PMC10154229 Free PMC article. https://www.nature.com/articles/s43587-021-00105-8