transcription factor TFIIIB component B homolog (transcription factor IIIB 150, TFIIIB150, transcription factor-like nuclear regulator, BDP1, KIAA1241, KIAA1689, TFNR)

Function

• general activator of RNA polymerase 3 transcription
• requires for transcription from all 3 types of RNA polymerase 3 promoters
• requires for transcription of genes with internal promoter elements & with promoter elements upstream of the initiation site
• component of TFIIIB complex.
• interacts with BRF1; this interaction diminishes during mitosis resulting in release of BDP1 from chromosomal templates
• component of TFIIIC complex
• interacts with ZBTB43
• phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin & suppression of RNA polymerase 3 transcription
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 1 Myb-like domain

Compartment

nucleus

Alternative splicing

named isoforms=8

Expression

• isoform 2 is highly expressed in cerebellum
• induced by epstein-Barr virus (EBV) resulting in the stimulation of the EBV EBER genes

More general terms

• transcription factor (TF)
• nuclear protein
• phosphoprotein

Component of

• TFIIIB
• transcription factor IIIC (TFIIIC)

Database

• OMIM: https://mirror.omim.org/entry/607012
• UniProt: http://www.uniprot.org/uniprot/A6H8Y1.html