mediator of RNA polymerase II transcription subunit 15; activator-recruited cofactor 105 kD component; ARC105; CTG repeat protein 7a; mediator complex subunit 15; positive cofactor 2 glutamine/Q-rich-associated protein; PC2 glutamine/Q-rich-associated protein; TPA-inducible gene 1 protein; TIG-1; trinucleotide repeat-containing gene 7 protein (MED15, ARC105, CTG7A, PCQAP, TIG1, TNRC7)

Function

• component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes
• positively regulates the nodal signaling pathway
• ubiquitinated by TRIM11, leading to proteasomal degradation
• interacts with WWTR1
• interacts with TRIM11

Structure

• belongs to the mediator complex subunit 15 family

Compartment

cytoplasm. nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte & placenta
• highest expression in placenta & peripheral blood
• lowest expression in pancreas & kidney
• induced by 12-O-tetradecanoylphorbol-13-acetate (TPA)

Polymorphism

• the poly-Gln region from amino acids 235-262 of MED15 is polymorphic
• there are from 15-18 repeats in the Italian population

More general terms

• transcription factor (TF)
• phosphoprotein

Component of

• activator-recruited cofactor (ARC)/DRIP
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51586
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51586
• OMIM: https://mirror.omim.org/entry/607372
• UniProt: http://www.uniprot.org/uniprot/Q96RN5.html