short transient receptor potential channel 5 (TrpC5, Htrp-5, Htrp5, TRP5)

Function

• forms a receptor-activated selective vs non-selective Ca+2 permeant cation channel
• probably regulated by phosphatidylinositol 2nd messenger system activated by receptor tyrosine kinases or G-protein coupled receptors
• may be activated by intracellular Ca+2 store depletion
• interacts with NHERF

Structure

• belongs to the transient receptor family, STrpC subfamily
• contains 2 ANK repeats

Compartment

membrane

Expression

expressed in brain, higher levels in fetal brain

More general terms

• Ca+2 channel
• transmembrane 6 protein

Database

• OMIM: https://mirror.omim.org/entry/300334
• UniProt: http://www.uniprot.org/uniprot/Q9UL62.html