transient receptor potential cation channel subfamily V member 2 (TrpV2, osm-9-like TRP channel 2, OTRPC2, vanilloid receptor-like protein 1, VRL-1, VRL)

Function

• non-selective Ca+2 channel with an outward rectification
• regulated by IGF1, PDGF, neuropeptide head activator
• may transduce physical stimuli in mast cells
• activated by temperatures higher than 52 degrees Celsius
• NOT activated by vanilloids or acidic pH
• interacts with PRKAR2A or PRKAR2B, ACBD3, RGA
• phosphorylated by PKA

Structure

• homotetramer (probable)
• N-glycosylated

Compartment

• cell membrane, cytoplasm, translocates from cytoplasm to plasma membrane upon ligand stimulation

More general terms

• transient receptor potential cation channel subfamily V (TRPV)
• Ca+2 channel
• transmembrane 6 protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/606676
• UniProt: http://www.uniprot.org/uniprot/Q9Y5S1.html