galectin-9 (soluble galactoside-binding lectin 9, HOM-HD-21, ecalectin, LGALS9)

Function

• binds galactosides
• may play a role in thymocyte-epithelial interactions relevant to the biology of the thymus
• short isoform acts as an eosinophil chemoattractant
• ligand for HAVCR2/TIM3
• induces T-helper type 1 lymphocyte (Th1) death

Structure

• contains two homologous but distinct carbohydrate-binding domains
• contains 2 galectin domains

Compartment

• cytoplasm (putative)
• secreted, may also be secreted by a non-classical secretory pathway (putative)

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

Expression

• expressed in peripheral blood leukocytes & lymphatic tissues

Pathology

overexpressed in Hodgkin's disease tissue

More general terms

• galaptin

Database

• UniProt: http://www.uniprot.org/uniprot/O00182.html
• OMIM: https://mirror.omim.org/entry/601879
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3965