hepatitis A virus cellular receptor 2 (HAVcr-2, T cell immunoglobulin & mucin domain-containing protein 3, TIMD-3, T cell membrane protein 3, TIM-3, HAVCR2, TIM3, TIMD3)

Function

• regulates macrophage activation
• inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- & alloimmune responses & promotes immunological tolerance
• role in T-cell homing
• receptor for LGALS9

Structure

• belongs to the immunoglobulin superfamily, TIM family
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

T-helper type 1 lymphocyte (Th1)-specific

Pathology

• hepatitis A virus cellular receptor
• genetic variation in HAVCR2 may influence susceptibility to rheumatoid arthritis

More general terms

• glycoprotein
• virus receptor

Database

• OMIM: https://mirror.omim.org/entry/180300
• OMIM: https://mirror.omim.org/entry/606652
• UniProt: http://www.uniprot.org/uniprot/Q8TDQ0.html