C-type lectin-like domain family 1 (dendritic cell-associated lectin 1, DC-associated lectin-1, DCAL-1, CLECL1, DCAL1)

Function

• may function in mediating immune cell-cell interactions
• may act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation
• may play a role in the interaction of dendritic cells with T-cells & the cells of the adaptive immune response

Structure

contains 1 C-type lectin domain

Compartment

cell membrane

Expression

• expressed in spleen, lymph node, & tonsil
• lower expression in peripheral blood, bone marrow, & colon
• no expression detected in thymus
• highly expressed in dendritic & B-cells

More general terms

• glycoprotein
• membrane protein
• C-type lectin superfamily

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1603
• OMIM: https://mirror.omim.org/entry/607467
• UniProt: http://www.uniprot.org/uniprot/Q8IZS7.html