CD276 (costimulatory molecule, B7 homolog 3, B7-H3, 4Ig-B7-H3, B7H3, PSEC0249, UNQ309/PRO352)

Function

• regulation of T-cell-mediated immune response (putative)
• inhibits natural-killer mediated cell lysis
• role in acute & chronic transplant rejection
• regulation of lymphocytic activity at mucosal surfaces
• role in placental & fetal immunity

Structure

• belongs to the immunoglobulin superfamily, BTN/MOG family
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
  • contains 2 Ig-like V-type domains (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• not detected in peripheral blood lymphocytes or granulocytes
• weakly expressed in resting monocytes
• expressed in dentritic cells derived from monocytes
• expressed in epithelial cells of sinonasal tissue
• expressed in extravillous trophoblast cells & Hofbauer cells 1st trimester & term placenta
• induced by LPS in monocytes & by ionomycin in T-cells & B-cells

Pathology

• marker for detection of neuroblastoma cells

More general terms

• CD antigen
• immunoglobulin superfamily protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/605715
• UniProt: http://www.uniprot.org/uniprot/Q5ZPR3.html