cyclin-dependent kinase 4 inhibitor C; p18-INK4c; cyclin-dependent kinase 6 inhibitor; p18-INK6 (CDKN2C, CDKN6)

Function

• interacts strongly with CDK6, weakly with CDK4
• inhibits cell growth & proliferation with a correlated dependence on endogenous retinoblastoma protein RB
• heterodimer of p18ink6 with CDK6

Structure

• belongs to the CDKN2 cyclin-dependent kinase inhibitor family
• contains 4 ANK repeats

Expression

• highest levels found in skeletal muscle
• also found in pancreas & heart

Pathology

defects in CDKN2C are involved in tumor formation

More general terms

• nuclear protein
• cyclin-dependent kinase inhibitor (CDKI, CDKN)
• ankyrin repeat domain protein (ANKRD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1031
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1031
• OMIM: https://mirror.omim.org/entry/603369
• UniProt: http://www.uniprot.org/uniprot/P42773.html