interleukin-28A; IL-28A; cytokine Zcyto20; interferon lambda-2; IFN-lambda-2 (IL28A, IFNL2, ZCYTO20)

Function

• immunomodulatory cytokine
• antiviral immunity
• up-regulates MHC class I antigen expression
• ligand for the heterodimeric class II cytokine recepto
  • signal through the Jak-STAT pathway.

Compartment

secreted

Expression

induction by viral infections or dsRNA

Notes

• uncertain whether Met-1 or Met-5 is the initiator

More general terms

• interleukin
• interferon [IFN]-lambda (IFNL)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=282616
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:282616
• OMIM: https://mirror.omim.org/entry/607401
• UniProt: http://www.uniprot.org/uniprot/Q8IZJ0.html