fibroblast growth factor 5; FGF-5; heparin-binding growth factor 5; HBGF-5; smag-82 (FGF5)

Function

• role in the regulation of cell proliferation & cell differentiation
• required for normal regulation of the hair growth cycle
• inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (putative)
• interacts with FGFR1 & FGFR2
• affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Structure

• belongs to the heparin-binding growth factors family

Compartment

secreted (putative)

Alternative splicing

• named isoforms=2; long, short
• short isoform seems to have an antagonistic effect compared to that of long isoform

Expression

• expressed in neonatal brain

Pathology

• can transform NIH 3T3 cells

More general terms

• fibroblast growth factor
• proto oncogene protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2250
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2250
• OMIM: https://mirror.omim.org/entry/165190
• UniProt: http://www.uniprot.org/uniprot/P12034.html