CMRF35-H antigen (CMRF35-H9, CMRF-35-H9, CD300a antigen, inhibitory receptor protein 60, IRp60, IRC1/IRC2, NK inhibitory receptor, CD300A, CMRF35H)

Function

• receptor with role in down-regulation of cytolytic activity in natural killer cells
• upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 & PTPN11/SHP-2

Structure

• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in natural killer cells, T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes, monocytes

More general terms

• CD300 family protein
• phosphoprotein
• cell surface receptor

Database

• OMIM: https://mirror.omim.org/entry/606790
• UniProt: http://www.uniprot.org/uniprot/Q9UGN4.html