EGF-like module-containing mucin-like hormone receptor-like 2; EGF-like module EMR2; CD312 antigen (CD312, EMR2)
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Function
- receptor probably involved in cell attachment
- forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety
- interacts with chondroitin sulfate
- proteolytically cleaved into 2 subunits, an extracellular alpha subunit & a seven-transmembrane subunit
Structure
- GPS domain is necessary, but not sufficient for receptor cleavage, which requires the entire extracellular stalk
- binding to chondroitin sulfate is mediated by the fourth EGF domain
- belongs to the G-protein coupled receptor 2 family LN-TM7 subfamily
- contains 5 EGF-like domains
- contains 1 GPS domain
Compartment
Alternative splicing
named isoforms=1
- a number of isoforms consisting of various number of EGF-like domains seems to exist
- a soluble form due to a frameshift which introduced a stop codon immediately before the first transmembrane domain is also detected
Expression
- expression is restricted to myeloid cells
- highest expression found in peripheral blood leukocytes, followed by spleen & lymph nodes
- intermediate to low levels in thymus, bone marrow, fetal liver, placenta, & lung,
- no expression in heart, brain, skeletal muscle, kidney, or pancreas
- expression detected in monocyte/macrophage & Jurkat cell lines but not in other cell lines tested