CD89; immunoglobulin alpha Fc receptor; IgA Fc receptor (FCAR)

Function

• mediates
  • cytokine production
  • phagocytosis
  • antibody-dependent cell-mediated cytotoxicity
  • release of inflammatory mediators
• binds Fc region of IgA
• associates with & induces tyrosine phosphorylation of Fc epsilon RI gamma 2 receptor

Structure

• contains 2 Ig-like C2-type domains (immunoglobulin-like)

Compartment

• membrane (isoform A)
• secreted (isoform B)

Alternative splicing

named isoforms=6; A.1,A.2,A.2,B,B-delta

Expression

• granulocyte lineage cells
• monocytes (isoforms A.1, A.2 & A.3)
• activated eosinophils
• alveolar macrophages (isoforms A.1 & A.2)
• splenic macrophages
• cells express only one isoform at their surfaces

More general terms

• CD antigen
• immunoglobulin superfamily protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P24071.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2204
• OMIM: https://mirror.omim.org/entry/147045
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2204