CD48; B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; Leukocyte antigen MEM-102; TCT.1 (BCM1, BLAST1)
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Function
- associates with/activates lck[1]
- ligand for CD2
- might facilitate interaction between activated lymphocytes
- probably involved in regulating T-cell activation
Structure
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment
cell membrane; lipid-anchor, GPI-anchor
Expression
- most leukocytes
- activated lymphocytes
- neutrophils & platelets stain negatively with antibody
Pathology
- numbers of CD48+ lymphocytes decreased in paroxysmal nocturnal hemoglobinuria
More general terms
References
- ↑ Jump up to: 1.0 1.1 Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/1281458
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=962
- ↑ UniProt http://www.uniprot.org/uniprot/P09326.html