CD39; ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; ecto-ATP diphosphohydrolase; ATPDase; lymphoid cell activation antigen; ecto-apyrase (ENTPD1)

Function

• inhibitor of platelet activation
• in the nervous system, may hydrolyze ATP & other nucleotides to regulate purinergic neurotransmission
• hydrolyzes ATP & ADP equally well

Cofactor: Ca+2, Mg+2

Structure

• homodimer, disulfide-linked (putative)
• the N-terminus is blocked
• palmitoylated in the N-terminal part
• belongs to the GDA1/CD39 NTPase family

Compartment

membrane (putative)

Alternative splicing

named isoforms=3

Expression

• B cells, T cells, NK cells
• endothelial cells
• placenta

More general terms

• CD antigen
• adenosine triphosphatase (ATPase)
• pyrophosphatase (diphosphohydrolase)
• glycoprotein
• membrane protein

Additional terms

• CD39 like protein (CD39 like antigen, CD39L, ectonucleoside triphosphate diphosphohydrolase)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:953
• OMIM: https://mirror.omim.org/entry/601752
• UniProt: http://www.uniprot.org/uniprot/P49961.html