granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 (CSF3R, GCSFR)

Function

• receptor for G-CSF
• regulates myeloid differentiation & proliferation
• also may function in some adhesion or recognition events at the cell surface

Structure

• dimer (probable)
• the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell- surface receptor binding
• the box 1 motif is required for JAK interaction &/or activation
• belongs to the type I cytokine receptor family, type 2 subfamily
• contains 5 fibronectin F3 modules
• contains 1 Ig-like C2-type domain (immunoglobulin-like)

Compartment

• isoform 2: secreted (probable)
• cell membrane
• isoform 2: secreted (probable)

Alternative splicing

• named isoforms=4
• additional isoforms seem to exist

Expression

• granulocytes
• monocytes
• platelets
• endothelium
• placenta
• trophoblastic cells
• one or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U937 cell line, in bone marrow cells, placenta, & peripheral blood granulocytes
• isoform GCSFR-2 is found only in leukemia U937 cells
• isoform GSCFR-3 is highly expressed in placenta
• eosinophils, lymphocytes, erythrocytes stain negatively with antibody

Pathology

-defects in CSF3R may be a cause of severe congenital neutropenia

More general terms

• hematopoietin receptor superfamily
• colony-stimulating factor [CSF] receptor
• oligomerizing protein
• CD antigen
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1441
• OMIM: https://mirror.omim.org/entry/138971
• UniProt: http://www.uniprot.org/uniprot/Q99062.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1441