prosalusin (torsin-2A, torsin family 2 member A, [Contains: Salusin-alpha; Salusin-beta], TOR2A)

Function

• salusin-alpha & salusin-beta are produced by proteolytic processing of prosalusin
• salusin-alpha & salusin-beta may be endocrine &/or paracrine factors able to increase intracellular Ca+2 & induce cell mitogenesis
• salusins may also be potent hypotensive peptides
• amidation of salusin-alpha(29-Gly) by peptidylglycine alpha- amidating monooxygenase, PAM, converts Lys-241-Gly-242 to Lys-241-NH2 & gives raise to salusin-alpha
• salusin-alpha & salusin-beta are only produced from an alternatively spliced mRNA of TOR2A, isoform 4

Structure

• belongs to the clpA/clpB family, torsin subfamily

Compartment

secreted

Alternative splicing

named isoforms=5

Expression

• isoform 4 is ubiquitously expressed, with high level in vascular endothelial cells & vascular smooth muscle cells

See 2 different UniProt Entries

More general terms

• glycoprotein
• protein precursor

Database

• OMIM: https://mirror.omim.org/entry/608052
• UniProt: http://www.uniprot.org/uniprot/Q8N2E6.html
• UniProt: http://www.uniprot.org/uniprot/Q5JU69.html