proglucagon

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Function

precursor for
post-translationally processed in a tissue-specific manner in pancreatic A cells & intestinal L cells
in pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2
in intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin & oxyntomodulin

More general terms

References

↑ Holz CG & Habener JF Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. TIBS 17:388 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1455507
↑ UniProt http://www.uniprot.org/uniprot/P01275.html

Database

UniProt: http://www.uniprot.org/uniprot/P01275.html
OMIM: https://mirror.omim.org/entry/138030

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