neuroendocrine (prohormone convertase-1, NEC-1, PC1/PC3, PCSK1)

Function

• role in the processing of hormone & other protein precursors at sites comprised of pairs of basic amino acid residues
• substrates include POMC, renin, enkephalin, dynorphin, somatostatin & insulin
• release of protein hormones, neuropeptides & renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds

Cofactor: Ca+2

Structure

belongs to the peptidase S8 family, Furin subfamily

Compartment

• cytoplasmic vesicle, secretory vesicle
• localized in the secretion granules

Pathology

• defects in PCSK1 are associated with obesity due to proprotein convertase 1 deficiency

More general terms

• neuroendocrine convertase; prohormone convertase (NEC)
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P29120.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5122
• OMIM: https://mirror.omim.org/entry/162150
• OMIM: https://mirror.omim.org/entry/600955