pro-opiomelanocortin; corticotropin-lipotropin (POMC)
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Function
- precursor for several anterior pituitary hormones
- ACTH stimulates the adrenal glands to release cortisol
- MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
- beta-endorphin & Met-enkephalin are endogenous opiates
- specific enzymatic cleavages at paired basic residues yield the different active peptides
- O-glycosylated
- reducing sugar is probably N-acetylgalactosamine
Structure
belongs to the POMC family
Compartment
Expression
- ACTH & MSH are produced by the pituitary gland
Pathology
- PMOC deficiency may be associated with susceptibility to obesity
More general terms
Additional terms
- adrenocorticotropic hormone; corticotropin; adrenocorticotropin (ACTH)
- corticotropin-like intermediary peptide (CLIP)
- lipotrophic hormone or lipotropin
- melanocyte-stimulating hormone (MSH)
References
- ↑ UniProt http://www.uniprot.org/uniprot/P01189.html
- ↑ Wikipedia; Note: melanocyte-stimulating hormone entry http://en.wikipedia.org/wiki/melanocyte-stimulating_hormone
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5443
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5443
- OMIM: https://mirror.omim.org/entry/176830
- OMIM: https://mirror.omim.org/entry/601665
- OMIM: https://mirror.omim.org/entry/609734
- UniProt: http://www.uniprot.org/uniprot/P01189.html