neuroendocrine convertase-2 (NEC-2, PC-2, KEX2-like endoprotease 2, PCSK2)

Function

• role in the processing of hormone & other protein precursors at sites comprised of pairs of basic amino acid residues
• release of protein hormones & neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|-bonds

Structure

belongs to the peptidase S8 family, Furin subfamily

Compartment

• cytoplasmic vesicle, secretory vesicle
• localized in the secretion granules

More general terms

• neuroendocrine convertase; prohormone convertase (NEC)
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P16519.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5126
• OMIM: https://mirror.omim.org/entry/162151