glucagon-like peptide 2 (GLP2)

Function

• derived from proglucagon
• stimulates intestinal growth & up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation & decreased enterocyte apoptosis
• the GI tract, from the stomach to the colon is the principal target for GLP-2 action.
• role in nutrient homeostasis
  • enhances nutrient assimilation through enhanced GI function
  • increases nutrient clearance
  • stimulates intestinal glucose transport
• decreases mucosal permeability

Expression

• GLP-1, GLP-2, oxyntomodulin & glicentin are secreted from enteroendocrine cells throughout the GI tract
• GLP-1 & GLP-2 are also secreted in selected neurons in the brain
• GLP-1 & GLP-2 are induced in response to nutrient ingestion

Pharmacokinetics

• 1/2life is 1-2 minutes

Comparative biology

• found in mammals only

More general terms

• incretin
• secretin family peptide
• endocrine agent

More specific terms

• teduglutide (Gattex)

Additional terms

• glucagon-like peptide 2 receptor; GLP-2 receptor; GLP-2-R; GLP-2R (GLP2R)

Database

• UniProt: http://www.uniprot.org/uniprot/P01275.html
• OMIM: https://mirror.omim.org/entry/138030