prodynorphin; proenkephalin-B; beta-neoendorphin-dynorphin; preprodynorphin; contains: alpha-neoendorphin; contains: beta-neoendorphin; contains: big dynorphin; big dyn; contains: dynorphin A(1-17); dynorphin A; dyn-A17; contains: dynorphin A(1-13); contains: dynorphin A(1-8); contains: Leu-enkephalin; contains: rimorphin; dynorphin B; dyn-B; dynorphin B(1-13); contains: leumorphin; dynorphin B-29 (PDYN)

Function

• Leu-enkephalins compete with & mimic the effects of opiate drugs; they play a role in a number of physiologic functions, including:
  • pain perception
  • responses to stress
• dynorphin peptides differentially regulate the kappa opioid receptor; dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (putative)
• Leumorphin has a typical opiod activity & may have anti-apoptotic effect (putative)

Structure

• the N-terminal domain contains 6 conserved Cys thought to be involved in disulfide bonding &/or processing
• belongs to the opioid neuropeptide precursor family

Compartment

secreted

More general terms

• peptide precursor

Database

• UniProt: http://www.uniprot.org/uniprot/P01213.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5173
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5173
• OMIM: https://mirror.omim.org/entry/131340