DnaJ homolog subfamily B member 6; heat shock protein J2; HSJ-2; MSJ-1; HHDJ1; MRJ (DNAJB6, HSJ2, MRJ, MSJ1)

Function

• role in the organization of KRT8/KRT18 filaments
• acts as an endogenous molecular chaperone for neuronal proteins including huntingtin
• has a stimulatory effect on the ATPase activity of HSP70 (dose-dependent & time-dependent manner)
• acts as a co-chaperone of HSP70
• reduces huntingtin aggregation associated with HD
• reduces cellular toxicity & caspase-3 activity
• interacts with ALKBH1 (putative)
• interacts with HSP70, KRT18 & PTTG

Structure

contains 1 J domain

Compartment

• cytoplasm, perinuclear region
• nucleus

Alternative splicing

named isoforms=3; A, B, C

Expression

• widely expressed
• highest levels in testis & brain
• lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver & leukocytes
• in testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids
• in brain, expressed at a higher level in hippocampus & thalamus & a lower level in amygdala, substantia nigra, corpus callosum & caudate nucleus

More general terms

• heat shock protein
• DNAJ homolog subfamily B
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10049
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10049
• OMIM: https://mirror.omim.org/entry/611332
• UniProt: http://www.uniprot.org/uniprot/O75190.html