FH1/FH2 domain-containing protein 3 (formin homolog overexpressed in spleen 2, hFHOS2, formactin-2, FHOD3, FHOS2, KIAA1695)
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Function
- actin-organizing protein
- may cause stress fiber formation together with cell elongation
- interacts with nestin/NES-based interfilament
Structure
- belongs to the formin homology family
- contains 1 DAD domain (diaphanous autoregulatory domain)
- contains 1 FH1 domain (formin homology 1 domain)
- contains 1 FH2 domain (formin homology 2 domain)
- contains 1 GBD/FH3 domain (Rho GTPase-binding/formin homology 3 domain)
Compartment
- cytoplasm, cytoskeleton
- main part of protein localizes to actin fibers
- remaining part displays filamentous staining
Alternative splicing
named isoforms=2
Expression
expressed in the heart, kidney & brain