centrosome-associated protein 350 (centrosome-associated protein 350, CEP350, CAP350, GM133)

Function

• required for anchoring microtubules to the centrosomes
• required for the integrity of the microtubule network
• recruits PPARA to discrete subcellular compartments & thus modulates PPARA activity
• component of a ternary complex that contains CEP350, FGFR1OP & MAPRE1
• interacts directly with FGFR1OP via its C-terminus
• interacts with NR1H3, PPARA, PPARD & PPARG
• phosphorylated during mitosis Strucutre: contains 1 CAP-Gly domain

Compartment

• centrosome, spindle, nucleus
• associated with mitotic spindles
• nuclear, in discrete foci
• associated with intermediate filaments

Expression

• detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney, pancreas

More general terms

• nuclear protein
• cytoskeletal protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5VT06.html