FGFR1 oncogene partenr (FGFR1OP, FOP)

Function

• anchoring microtubules to the centrosomes
• ternary complex that contains CEP350, FGFR1OP, MAPRE1
• interacts directly with CEP350, MAPRE1

Structure

• homodimer
• contains 1 LisH domain

Compartment

centrosome, associated with gamma-tubulin

Alternative splicing

named isoforms=3

Expression

• ubiquitous
• expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, pancreas

Pathology

• chromosomal translocation t(6;8)(q27;p11) with FGFR1 may be a cause of stem cell myeloproliferative disorder

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605392
• UniProt: http://www.uniprot.org/uniprot/O95684.html