twinfilin-2; A6-related protein; hA6RP; protein tyrosine kinase 9-like; twinfilin-1-like protein (TWF2, PTK9L, MSTP011)

Function

• actin-binding protein
• motile & morphological processes
• inhibits actin polymerization, sequesters G-actin
• capping the barbed ends of actin filaments
• clathrin-mediated endocytosis
• distribution of endocytic organelles
• interacts with G-actin, ADP-actin, & actin capping protein
• interacts with PTK9, phosphoinositides, PI(4,5)P2
• binding to PI(4,5)P2, down-regulates
• phosphorylated by PRKCZ, CK2, SRC

Structure

• belongs to the actin-binding proteins ADF family Twinfilin subfamily
• contains 2 ADF-H domains

Compartment

• cytoplasm, perinuclear
• G-actin-rich cortical actin structures

Expression

ubiquitously expressed

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11344
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11344
• OMIM: https://mirror.omim.org/entry/607433
• UniProt: http://www.uniprot.org/uniprot/Q6IBS0.html