leucine zipper tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1)

Function

• role in regulation of cell growth
• may stabilize active CDC2-cyclin B1 complex
• role as tumor suppressor (putative)
• binds EEF1G & CDC2
• phorphorylated on Ser
  • hyperphosphorylated by cAMP-dependent kinase PKA during cell-cycle progression

Structure

• belongs to the LZTS family

Compartment

• cytoplasm, cell membrane
• associated with plasma membrane & with microtubules
• detected in dendritic spines, especially in the postsynaptic density

Alternative splicing

named isoforms=7

Expression

• expressed in testis, prostate, spleen, thymus, ovary, brain > heart, placenta, small intestine, colon, liver, kidney, skeletal muscle, pancreas

Pathology

• not detectable in primary tumors from breast & prostate & in many cancer cell lines
• defects in LZTS1 are found in many types of tumors

More general terms

• myristoylated protein
• anti-oncoprotein (tumor suppressor protein)
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606551
• UniProt: http://www.uniprot.org/uniprot/Q9Y250.html