glucocorticoid receptor DNA-binding factor 1; glucocorticoid receptor repression factor 1; GRF-1; Rho GAP p190A; p190-A (GRLF1, GRF1, ARHGAP35, KIAA1722)

Function

• represses transcription of the glucocorticoid receptor by binding to cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'
• regulation of retinal development & degeneration
• may transduce signals from p21-ras to nucleus, acting via ras GTPase-activating protein (GAP)
• may also act as a tumor suppressor
• interacts with p120GAP
• Ser & Tyr phosphorylated

Structure

• contains 4 FF domains
• contains 1 Rho-GAP domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• anti-oncoprotein (tumor suppressor protein)
• rho GTPase-activating protein (rho-GAP)

Additional terms

• glucocorticoid receptor; GR; nuclear receptor subfamily 3 group C member 1 (NR3C1, GRL)

Database

• OMIM: https://mirror.omim.org/entry/605277
• UniProt: http://www.uniprot.org/uniprot/Q9NRY4.html