3-ketodihydrosphingosine reductase; KDS reductase; 3-dehydrosphinganine reductase; follicular variant translocation protein 1; FVT-1 (KDSR FVT1)

Function

• catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)
• lipid metabolism; sphingolipid metabolism

sphinganine + NADP+ <--> 3-dehydrosphinganine + NADPH

Structure

• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

• endoplasmic reticulum membrane

Expression

• expressed in all tissues examined
• highest expression in placenta
• high expression in lung, kidney, stomach & small intestine
• low expression in heart, spleen & skeletal muscle
• weakly expressed in normal hematopoietic tissues
• higher expression in some T-cell malignancies & PHA-stimulated lymphocytes

Pathology

• chromosomal translocation t(2;18)(p11;q21) involving KDSR with a Ig J kappa chain region is a cause of follicular lymphoma (chronic lymphatic leukemia type 2)

More general terms

• proto oncogene protein
• transmembrane 2 protein
• oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/Q06136.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2531
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2531
• OMIM: https://mirror.omim.org/entry/136440