tRNA selenocysteine-associated protein 1 (SECp43, TRSPAP1, SECP43, TRNAU1AP)

Function

• role in the early steps of selenocysteine biosynthesis & tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins
• stabilizes the SECISBP2, EEFSEC & tRNA(Sec) complex
• may be involved in the methylation of tRNA(Sec)
• enhances efficiency of selenoproteins synthesis (putative)
• component of the tRNA(Sec) complex
• interacts with SEPSECS
• associates with mRNP &/or polysomes (putative)

Structure

• belongs to the RRM TRSPAP family
• contains 2 RRM (RNA recognition motif) domains

Compartment

• nucleus, cytoplasm
• abundant in the nucleus (putative)

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• RNA-binding protein

Component of

• tRNA(Sec) complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NX07.html