selenocysteine insertion sequence-binding protein 2; SECIS-binding protein 2 (SECISBP2, SBP2)

Function

• binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins; binding is stimulated by SELB
• interacts with SELB (putative)

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

expressed at high levels in testis

Pathology

• defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism

More general terms

• RNA-binding protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79048
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79048
• OMIM: https://mirror.omim.org/entry/607693
• OMIM: https://mirror.omim.org/entry/609698
• UniProt: http://www.uniprot.org/uniprot/Q96T21.html