nuclear RNA export factor 3 (TAP-like protein 3, TAPL-3, NXF3, TAPL3)

Function

• tissue-specific nuclear mRNA export factor
• interacts with NXT1, NXT2, E1B-AP5 & CRM1 nuclear export factor

Structure

• lacks C-terminal domain that mediates direct interactions with nucleoporins
• contains a novel CRM1-dependent nuclear export signal that compensates in cis for loss of nuclear pore targeting domain
• belongs to the NXF family
• contains 1 LRR repeat (leucine-rich repeat
• contains 1 NTF2 domain
• contains 1 RRM domain (RNA recognition motif) domain
  • RNA-binding domain is a non-canonical RNP-type domain

Compartment

• nucleus, cytoplasm
• shuttles between nucleus & cytoplasm

Expression

• expressed at high level in testis & at low level other tissues

More general terms

• RNA-binding protein
• testis-specific protein

Database

• OMIM: https://mirror.omim.org/entry/300316
• UniProt: http://www.uniprot.org/uniprot/Q9H4D5.html