nuclear RNA export factor 5 (TAP-like protein 1, TAPL-1, NXF5, TAPL1)

Function

• export of mRNA from nucleus to cytoplasm (putative)
• role in polarized cytoplasmic transport & localization of mRNA in neurons
• interacts with NXT1 & NXT2 via NTF2 domain

Structure

• belongs to the NXF family
• contains 4 LRR repeats (leucine-rich repeats)
• contains 1 NTF2 domain
• contains 1 RRM domain (RNA recognition motif)

Compartment

• cytoplasm, nucleus
• mainly localized in the cytoplasm of cells, more particularly in the cell body & neurites of hippocampal neurons
• nuclear localization is also observed
• not detected at nuclear rim

Alternative splicing

named isoforms=5

Pathology

• chromosomal rearrangement, known as pericentric inversion inv(X)(p21.1;q22), produces interruption of NFX5, observed in one patient with a syndromic form of mental retardation & short stature

More general terms

• RNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/300319
• UniProt: http://www.uniprot.org/uniprot/Q9H1B4.html