nuclear RNA export factor 2 (TAP-like protein 2, TAPL-2, NXF2, TAPL2)

Function

• role in export of mRNA from nucleus to cytoplasm via leucine-rich repeats & NTF2-domain
• interacts with NXT1, NXT2, E1B-AP5, the REF proteins & with nucleoporins, Nup62, Nup153 & Nup214
• formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export

Structure

• belongs to the NXF family
• contains 4 LRR repeats (leucine-rich repeats)
  • contains 1 NTF2 domain
    • NTF2 domain heterodimerizes with NXT1 & NXT
  • contains 1 RRM domain (RNA recognition motif)
  • contains 1 TAP domain

Compartment

• nucleus, nucleoplasm, cytoplasm
• localized in nucleoplasm & at the nuclear envelope
• shuttles between nucleus & cytoplasm

Expression

• expressed almost exclusively in testis

More general terms

• RNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/300315
• UniProt: http://www.uniprot.org/uniprot/Q9GZY0.html