Ca+2 uptake protein 1, mitochondrial; atopy-related autoantigen CALC; ara CALC; Ca+2-binding atopy-related autoantigen 1; allergen hom s 4 (MICU1 CALC CBARA1)

Function

• induces T helper 1-mediated autoreactivity, which is accompanied by the release of IFNG
• regulator of mitochondrial Ca+2 uptake required for Ca+2 entry into mitochondria
• may act as a Ca+2 sensor via its EF-hand domains, gating activity of a Ca+2 channel partner.
• interacts with MCU

Structure

• the EF-hand domains are required for mitochondrial Ca+2 homeostasis function
• contains 2 EF-hand domains

Compartment

mitochondrial inner membrane (putative)

Alternative splicing

named isoforms=5

Expression

• expressed in epithelial cell line
• strongly expressed in epidermal keratinocytes & dermal endothelial cells

Pathology

• causes an allergic reaction in human
• binds to IgE from atopic dermatitis patients
• identified as an IgE autoantigen in atopic dermatitis patients with severe skin manifestations

More general terms

• Ca+2 binding protein
• mitochondrial membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10367
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10367
• OMIM: https://mirror.omim.org/entry/605084
• UniProt: http://www.uniprot.org/uniprot/Q9BPX6.html