scotin; NFkB activating protein 120 (SHISA5)

Function

• can induce apoptosis (caspase-dependent)
• role in p53/TP53-dependent apoptosis

Structure

• proline-rich region is required for endoplasmic reticulum localization

Compartment

endoplasmic reticulum membrane, nuclear membrane

Alternative splicing

named isoforms=4

Expression

• induced in response to cellular stress (p53-dependent)

More general terms

• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/607290
• UniProt: http://www.uniprot.org/uniprot/Q8N114.html