K+ channel subfamily T member 2 (sequence like an intermediate conductance K+ channel subunit, Na+ & chloride-activated ATP-sensitive K+ channel Slo2.1, KCNT2, SLICK)

Function

• outward rectifying K+ channel
• produces rapidly activating outward rectifier K(+) currents
• activated by high intracellular Na+ & Cl- levels
• channel activity is inhibited by ATP & by inhalation anesthetics, including as isoflurane
• inhibited upon stimulation of G-protein coupled receptors, including as CHRM1 & GRIA1
• phosphorylated by protein kinase C
• phosphorylation of the C-terminal domain inhibits channel activity

Structure

• belongs to the K+ channel family
• Ca+2-activated subfamily
• contains 1 RCK N-terminal domain

Compartment

cell membrane

Alternative splicing

named isoforms=4

More general terms

• transmembrane 6 protein
• K+ channel subfamily T
• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6UVM3.html