xylosyltransferase 2 (XylT-2, peptide O-xylosyltransferase 1, XYLT2, XT2, UNQ3058/PRO9878)

Introduction

Functin:

• catalyzes 1st step in biosynthesis of glycosaminoglycan
• transfers D-xylose from UDP-D-xylose to specific Ser of the core protein
• initial enzyme in biosynthesis of chondroitin sulfate & dermatan sulfate proteoglycans in fibroblasts & chondrocytes
• enzyme activity has not been demonstrated
• transfers a beta-D-xylosyl residue from UDP-D-xylose to Ser hydroxy group of an acceptor protein

Cofactor: divalent cations

Structure

• monomer
• contains disulfide bonds
• belongs to the glycosyltransferase 14 family, XylT subfamily

Compartment

• endoplasmic reticulum membrane. Golgi membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• xpressed at higher level in kidney & pancreas

More general terms

• glycosyltransferase
• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/608125
• UniProt: http://www.uniprot.org/uniprot/Q9H1B5.html