inactive dipeptidyl peptidase 10 (dipeptidyl peptidase X, dipeptidylpeptidase-like protein 2, DPL2, dipeptidyl peptidase IV-related protein 3, DPRP-3, DPP10, DPRP3, KIAA1492)

Function

• no dipeptidyl aminopeptidase activity
• may modulate cell surface expression & activity of K+ channels KCND1 & KCND2

Structure

• may form oligomers
• N-glycosylated
• belongs to the peptidase S9B family, DPPIV subfamily

Compartment

membrane

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist, which may have different subcellular locations

Expression

• found in serum, T-cells & brain
• expressed in brain, pancreas, spinal cord, adrenal glands

Pathology

• defects in DPP10 may be a cause of susceptibility to asthma defects in splicing have been observed

More general terms

• membrane protein
• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/608209
• UniProt: http://www.uniprot.org/uniprot/Q8N608.html