retinol dehydrogenase 11 (retinal reductase 1, RalR1, prostate short-chain dehydrogenase/reductase 1, androgen-regulated short-chain dehydrogenase/reductase 1, HCV core-binding protein HCBP12, RDH1,1 ARSDR1, PSDR1, CGI-82)

Function

• oxidoreductive catalytic activity towards retinoids
• most efficient as an NADPH-dependent retinal reductase
• high activity toward 9-cis & all-trans-retinol
• metabolism of short-chain aldehydes
• no steroid dehydrogenase activity
• induced by androgens, in prostate cancer cells

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• expressed in the epithelial cells of prostate, in both basal & luminal secretory cell populations
• expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland, fetal liver
• Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes

More general terms

• retinal dehydrogenase
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/607849
• UniProt: http://www.uniprot.org/uniprot/Q8TC12.html