signal peptide, CUB & EGF-like domain-containing protein 1 (SCUBE1)

Function

• adhesive molecule (putative)
• matrix bound & soluble fragments may play role in vascular system
• forms homo-oligomers & hetero-oligomers with SCUBE2 & SCUBE3
• Could be proteolytically cleaved to release a smaller active fragment

Structure

• N-glycosylated
• contains 1 CUB domain
• contains 9 EGF-like domains

Compartment

• secreted, cell membrane, peripheral membrane
• stored in platelet alpha granules, transferred to the cell surface upon activation and aggregation

Expression

• expressed in endothethelial cells, platelets
• down-regulated by inflammatory cytokines

Pathology

• smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus & localized with the subendothelial matrices in atherosclerotic plaques

More general terms

• EGF-like domain-containing protein (EGFL)
• secreted protein
• membrane protein
• glycoprotein

Additional terms

• signal peptide, CUB & EGF-like domain-containing protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IWY4.html