trophoblast glycoprotein (5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, 5T4 oncofetal antigen, M6P1, TPBG 5T4)

Structure

• contains 7 LRR repeats (leucine-rich repeats)

Compartment

membrane

Expression

• expressed by all types of trophoblasts as early as 9 weeks of development
• specific for trophoblastic cells except for amniotic epithelium
• in adult tissues, expression is limited to a few epithelial cell types

Pathology

• overexpressed by a wide spectrum of cancers, including colorectal carcinoma, ovarian cancer, gastric cancer

More general terms

• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/190920
• UniProt: http://www.uniprot.org/uniprot/Q13641.html